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Cautions

Increased blood CPK levels and rhabdomyolysis reported

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Antiepileptic drugs increase risk of suicidal thoughts or behavior in patients taking these drugs for any indication; monitor for emergence or worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior

Anaphylaxis and angioedema reported after first dose or at any time during treatment; instruct patients to discontinue therapy and seek medical care should they interactions experience signs or symptoms of anaphylaxis or angioedema

May cause CNS depression, which may impair ability to operate heavy machinery; advise patients not to drive until they have gained enough experience to assess whether therapy will impair ability to drive

Extended release formulation (Garlise) not studied in the treatment of seizures

Extended release formulation (Garlise), not interchangeable with immediate release

May potentiate effects of other sedatives or ethanol when administered concomitantly

Do not discontinue abruptly (may increase seizure frequency); gradually taper over a minimum of 1 week

Ages 3-12 years: Risk of neuropsychiatric adverse events, including emotional lability, hostility, thought disorders, and hyperkinesia

Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as multiorgan hypersensitivity, reported; some of these events have been fatal or life-threatening; typically presents with fever, rash, and/or lymphadenopathy in association with other organ system involvement (eg, hepatitis, nephritis, hematologic abnormalities, myocarditis, myositis) and may resemble an acute viral infection


Source: http://reference.medscape.com/drug/neurontin-gralise-gabapentin-343011


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