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Testosterone and dopamine are intimately connected in a bidirectional relationship. Testosterone regulates dopamine and dopamine testosterone. Because many of the men that show up to my site are low testosterone, I want to start with the research that shows that testosterone profoundly affects brain dopamine levels. Testosterone profoundly affects many other neurotransmitters as well, which I over in my link on viagra Testosterone and the Brain.

Here are three keys ways that testosterone and dopamine influence each other:

1. MPOA (Medial Preoptic Area). This region of the brain sits near the hippocampus and is critical for the bedroom. If this area is injured, animal studies show that no copulation will occur. And one study in rats showed this by microinjecting dopamine stimulators into the MPOA, which increased mountings, and dopamine suppressors, which did the opposite. [1] Therefore, it is obviously dopamine in this region that is one of the key gatekeepers.

What testosterone have to do with this?  Research, again in animals, has shown that testosterone controls dopamine release in the MPOA. In fact, castrated animals show no interest in mounting and had no dopamine release in the MPOA.  Castrated animals given testosterone, however, would do their duty with a female AND had the necessary dopamine release. [2] The clear takeaway:  testosterone governs dopamine release in key areas of the brain.

2.  Low Testosterone Can Destroy Dopamine.  So testosterone can stimulate release of brain dopamine and low testosterone can inhibit it.  However, preliminary evidence shows that low testosterone can have a much more nefarious side and may play a role in Parkinson's Disease.  Of course, Parkinson's is the well-known condition that afflicts over a million people and is characterized by muscle rigidity and tremors due to loss of brain dopamine levels. 


Source: http://www.peaktestosterone.com/Testosterone_Dopamine.aspx


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